Despite improvements in analgesic treatment following total knee arthroplasty (TKA) for osteoarthrosis, a substantial part of patients still have severe acute pain after surgery. It has been suggested that preoperative degree of intraarticular inflammation is associated to postoperative degree of pain and level of function. Furthermore it is known, that patients with preoperative inflammation have hyperalgesia and severe movement related pain. The aim of this study is to investigate the effect of a preoperative intraarticular injection of Methylprednisoloneacetate in reducing acute postoperative pain after total knee arthroplasty in patients with signs of severe pre-operative inflammation and pain.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
48
Gentofte Hospital
Hellerup, Denmark
Pain
Pain intensity on a numeric rang scale (NRS) from 0 to 10 upon ambulation 24 hours following surgery
Time frame: 24 hours postoperatively
Pain
Pain intensity on a NRS from 0 to 10 upon ambulation 48 hours following
Time frame: 48 hours postoperatively
Pain
Diary-reported pain intensity on a NRS from 0 to 10 when walking. Once daily from first to fourteenth postoperative day
Time frame: From day 1 to day 14
Pain
Diary-reported pain intensity on a NRS from 0 to 10 upon rest. Once daily from first to fourteenth postoperative day
Time frame: From day 1 to day 14
Sensitisation
Quantitative sensory testing (temporal summation / pressure algometry) on the day of surgery and on the second postoperative day.
Time frame: On day 0 and day 2
Inflammation
Measurement of C-reactive protein in blood sample on the day of surgery and on the second postoperative day.
Time frame: On day 0 and day 2
Inflammation
Measurement of interleukin-6 level in knee joint fluid on the day of surgery.
Time frame: On day 0
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