Pharmacokinetics of Salmeterol (Serevent®) After Inhalation With Metered Dose Inhaler (MDI) and Diskus® in Healthy Male Volunteers

Inclusion Criteria: 1. Healthy males according to the following criteria: Based upon a complete medical history, including the physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead ECG (electrocardiogram) , clinical laboratory tests 1.1 No finding deviating from normal and of clinical relevance 1.2 No evidence of a clinically relevant concomitant disease 2. Age ≥21 and ≤50 years 3. BMI ≥18.5 and \<30 kg/m2 (Body Mass Index) 4. Signed and dated written informed consent prior to admission to the study in accordance with Good Clinical Practice (GCP) and the local legislation. Exclusion Criteria: 1. Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders 2. Surgery of gastrointestinal tract (except appendectomy) 3. Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders 4. History of relevant orthostatic hypotension, fainting spells or blackouts. 5. Chronic or relevant acute infections 6. History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator 7. Intake of drugs with a long half-life (\>24 hours) within at least 1 month or less than 10 half-lives of the respective drug prior to administration or during the trial. 8. Use of drugs which might reasonably influence the results of the trial based on the knowledge at the time of protocol preparation within 10 days prior to administration or during the trial. 9. Participation in another trial with an investigational drug within 2 months prior to administration or during the trial. 10. Smoker (more than 10 cigarettes or three cigars or three pipes per day) 11. Inability to refrain from smoking on trial days 12. Alcohol abuse (more than 60 g/day) 13. Drug abuse 14. Blood donation (more than 100 mL within 4 weeks prior to administration or during the trial) 15. Excessive physical activities (within 1 week prior to administration or during the trial) 16. Any laboratory value outside the reference range that is of clinical relevance 17. Inability to comply with dietary regimen of study centre Exclusion criterion specific for this study: 18. Asthma or history of pulmonary hyperreactivity 19. Allergy / hypersensitivity to Lactose monohydrate 20. Hyperthyrosis 21. Allergic rhinitis in need of treatment 22. Cardiac arrhythmia 23. Paroxysmal tachycardia (\> 100 beats per minute) 24. Aortic stenosis