Open surgery for aneurysmal aortic disease can lead to cardiac, renal, pulmonary or muscular complications, essentially due to the aortic clamping. Ischemic preconditioning can be useful in order to decrease these complications. The investigators would like to use an ischemic preconditioning protocol during open surgery of aortic aneurysm in order to decrease these complications.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
59
Ischemic preconditioning during aortic clamping
Procedure/Surgery: usual surgery
Service de Chirurgie Vasculaire, CH Jean Minjoz
Besançon, France
Service de Chirurgie Vasculaire, CHU le Bocage
Dijon, France
Service de Chirurgie vasculaire et transplantation rénale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg
Strasbourg, France
Service de Chirurgie Vasculaire, Hôpitaux Privés de Metz, Site de Mercy
Vantoux, France
Myocardial damage measured by troponin level > 0.4 microgr/L (day 1)
Myocardial damage measured by Troponin I level \> 0.4 microg/L
Time frame: Day 1
Renal damage
Renal damage measured with Post-operative Creatinin clearance \< 50% of Pre-operative creatinin clearance
Time frame: Day 0, day 1, day 3 or day 5.
Muscle weakness
Muscle weakness measured by Creatine phospho Kinase \> 200 UI/L
Time frame: Day 0, day 1, day 3 or day 5
Myocardial damage measured by troponin level > 0.4 microgr/L
Time frame: Day 0, 3, or 5
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