Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
12
University Hospital
Basel, Switzerland
regional brain activity assessed by functional Magnetic Resonance Imaging (fMRI)
Changes in resting state functional connectivity
Time frame: changes from baseline to one hour after treatment
gastrointestinal satiation peptide secretion
Unit of Measure: glucagon like peptide-1 (GLP-1) in pg/mL, peptide tyrosine tyrosine (PYY) in pg/mL and gastric inhibitory polypeptide (GIP) in pg/mL
Time frame: changes from baseline to one hour after treatment
glucose and insulin secretion
Unit of Measure: glucose in mmol/L, insulin in μU/mL
Time frame: changes from baseline to one hour after treatment
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