Investigation of Iron Bioavailability from extruded rice grains fortified with Ferric Pyrophosphate alone or in combination with different Zinc Compounds; Ferrous Sulfate serves as a Reference.
Ferric Pyrophosphate (FePP) is a water-insoluble, food grade, iron compound widely used to fortify rice and other foods as it causes no organoleptic changes to the food vehicles. However, it is only of low absorption in man and its absorption can be influenced by a variety of compounds. The effect of co-fortification of rice with ZnO respectively ZnSO4 on iron bioavailability in extruded rice fortified with FePP has never been investigated.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
20
Rice fortified with Ferric Pyrophosphate and Zinc Oxide (ZnO)
Rice fortified with Ferrous Sulfate (ZnSO4)
Rice fortified with Ferric Pyrophosphate and Zinc Sulfate
ETH Zürich, Laboratory of Human Nutrition
Zurich, Canton of Zurich, Switzerland
Change from baseline in the isotopic ratio of iron in blood at week 2
The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes.
Time frame: baseline, 2 weeks
Change from week 2 in the isotopic ratio of iron in blood at week 4
The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes.
Time frame: 2 weeks, 4 weeks
Change from week 4 in the isotopic ratio of iron in blood at week 6
The change in the isotopic ratio of iron will be measured after the administration of test meal including iron isotopes.
Time frame: 4 weeks, 6 weeks
Haemoglobin
14 or 15 days after each meal administration and at baseline
Time frame: baseline, 16th, 30th and 44th day
Plasma Ferritin
14 or 15 days after each meal administration and at baseline
Time frame: baseline, 16th, 30th and 44th day
C reactive protein
14 or 15 days after each meal administration and at baseline
Time frame: baseline, 16th, 30th and 44th day
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Rice fortified with Ferric Pyrophosphate