Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation

Inje University68 enrolled

Overview

Compare the effects of intravenous midazolam and ketamine on emergence agitation after sevoflurane anesthesia

Emergence agitation is self-limiting aggressive behavior that develops in the early period of awakening from anesthesia. A high level of preoperative anxiety is a risk factor for emergence agitation using Aono's four-point scale. Midazolam and ketamine was administered to the patients to decrease of preoperative anxiety. We aimed to compare the emergence agitation between midazolam group and ketamine group.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Psychomotor Agitation

Interventions

MidazolamDRUG

preoperatively injected intravenous 0.1 mg/kg midazolam

KetamineDRUG

Preoperatively injected intravenous 1mg/kg ketamine

Eligibility

Sex: ALLMin age: 2 YearsMax age: 6 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American society of anesthesiologists physical status 1-2 aged 2-6 years old, who were scheduled to undergo ophthalmic surgery (\<2hr) Exclusion Criteria: * children with central nervous system disorders,history of allergy to the study drugs (midazolam and ketamine), history of recent respiratory tract infection

Outcomes

Primary Outcomes

Emergence Agitation

The primary endpoint is the incidence of postoperative emergence agitation that was defined as an Aono's four-point scale(AFPS) score of 3 or higher.

Time frame: During 30 minutes after extubation at post-anesthetic care unit, every 5 minutes

Data from ClinicalTrials.gov

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