A Pilot Study of Neoadjuvant Therapy With Gemcitabine and Cisplatin in Patients With Resectable or Unresectable Intrahepatic Cholangiocarcinoma

Inclusion Criteria: * Participants must meet the following criteria on screening examination to be eligible to participate in the study: * Participants must have histologically confirmed Intrahepatic Cholangiocarcinoma (IHC) without evidence of extrahepatic metastasis. * Participants must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques or as ≥10 mm with spiral CT scan. * Participants with resectable disease must have a single tumor (with no satellite lesions) with a total diameter or longest dimension of ≤ 20cm. Patients with unresectable disease must have a total tumor diameter of \<20cm and ≤ 3 lesions. Satellite lesions defined as lesions ≤ 2cm from the dominant lesion are permitted for participants with unresectable disease * Patients are not allowed to receive prior surgery or chemotherapy for the IHC. * Patients with age ≥18 will be included in the study. * Expected survival must be three months or greater. * ECOG performance status ≤ 2 (Karnofsky ≥ 70%, see Appendix A). * Participants must have normal organ and marrow function as defined below: * Absolute neutrophil count ≥ 1,500/mcL * Platelets ≥ 100,000/mcL * Total bilirubin ≤ 2.5 mg/dl * AST (SGOT)/ALT (SGPT) ≤ 5.0 X institutional upper limit of normal * Creatinine within normal institutional limits or creatinine clearance ≥ 60 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal . * No other known active secondary primary malignancy. * If patient has underlying cirrhosis, only Child-Pugh classification Group A patients may be included in the resectable cohort of this study. For patients with unresectable disease, Child-Pugh classification Groups A and B are allowed. Clinical assessment of ascites and encephalopathy is required. Child-Pugh classification must be determined for all study participants at the time of eligibility analysis. Note albumin and PT/INR are required for Child-Pugh classification; these labs should be drawn with the other labs required for eligibility analysis. Table 1: Child-Pugh classification of liver function * Score 1 2 3 * Ascites Absent Slight to moderate Severe * Encephalopathy Absent Slight to moderate Severe * Serum albumin \>3.5 g/dl 3-3.5 g/dl \<3 g/dl * Serum bilirubin \<2 mg/dl 2-3 mg/dl \>3 mg/dl * Prolongation of prothrombin time \<4 seconds 4-6 seconds \>6 seconds * Score of 5 to 6 corresponds to Child-Pugh class A * Score of 7 to 11 corresponds to Child-Pugh class B * Score of 12 to 15 corresponds to Child-Pugh class * The effects of gemcitabine+cisplatin on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study treatment. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. Female patients of child bearing potential must indicate to their physician that they are not pregnant at the time of enrollment or have a negative serum pregnancy test. * Ability to understand and the willingness to sign a written informed consent document. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Participants who exhibit any of the following conditions at screening will not be eligible for admission into the study. * Participants who have had chemotherapy or radiotherapy for intrahepatic cholangiocarcinoma. * Participants receiving any other anti-cancer or investigational agents. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to gemcitabine or cisplatin. * Women who are pregnant or lactating. * Participants with evidence of non-hepatic metastatic disease. * Local conditions or systemic illnesses which would reduce the local tolerance to radiation treatment, such as serious local injuries, active collagen vascular disease, etc. * Participants with a serious medical illness which may limit expected survival to less than 3 months. * Participants with serious psychiatric illness or social situations which would limit adherence to study requirements. * Participants receiving any medications or substances that are strong inhibitors or inducers of CYP3A4 are ineligible. * Because no dosing or adverse event data are currently available on the use of gemcitabine+cisplatin in participants \<18 years of age, children are excluded from this study. * Patients who require anticoagulation should receive low-molecular weight or standard heparin and not warfarin. * Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Pregnant women are excluded from this study because gemcitabine is a class D agent with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk of adverse events in nursing infants secondary to treatment of the mother with gemcitabine, breastfeeding should be discontinued if the mother is treated with gemcitabine. These potential risks may also apply to other agents used in this study. * Individuals with a history of a different malignancy are ineligible except for the following circumstances. Individuals with a history of other malignancies are eligible if they have been disease-free for at least 5 years and are deemed by the investigator to be at low risk for recurrence of that malignancy. Individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, DCIS, stage I prostate cancer, and basal cell or squamous cell carcinoma of the skin. * HIV-positive individuals on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with gemcitabine+cisplatin. In addition, these individuals are at increased risk of lethal infections when treated with marrow-suppressive therapy. Appropriate studies will be undertaken in participants receiving combination antiretroviral therapy when indicated. HIV-positive individuals on HAART will be considered eligible of they have demonstrated good compliance and have a CD4 count \> 500. * Prior liver directed radiation. * Patients with peripheral neuropathy ≥ grade 2.