Exercise in the Fasted State, Glucose Metabolism and Energy Balance

University of Bath12 enrolled

Overview

The ability to control our blood glucose (sugar) concentrations after a meal is a strong predictor of the risk of disease. Our bodies respond to glucose ingestion by reducing the amount of glucose from the liver entering the bloodstream. At the same time muscle increases the amount of glucose it take up from the bloodstream. This ensures that our blood glucose levels do not get too high. The investigators want to understand what happens to these processes following exercise after breakfast and after an overnight fast. In addition, the investigators also want to understand whether exercising with or without breakfast influences our appetite, food intake and activity levels later in the day.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Energy Balance Blood Glucose

Interventions

Eligibility

Sex: MALEMin age: 18 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Males. * Aged 18-49. * Individuals free from known cardiovascular, metabolic or joint disease as determined by standard health questionnaire. * Habitual regularly participating in exercise (minimum of 3 sessions per week on average) * Non-smoker Exclusion Criteria: * Known or suspected food intolerances, allergies or hypersensitivity. * Any bleeding disorder or taking medication which impacts blood coagulation. * Known tendency towards keloid scarring. * Known sensitivity or allergy to any local anaesthetic medicines. * Any reported use of substances which may pose undue personal risk to participants or introduce bias into the experiment. * Any other condition or behaviour deemed either to pose undue personal risk to participants or introduce bias into the experiment.

Outcomes

Primary Outcomes

Exogenous glucose appearance rate

Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).

Time frame: 120 minutes

Energy balance

Energy balance (intake minus expenditure) over 24 h from the beginning of the trial

Time frame: 24 hours

Secondary Outcomes

Endogenous glucose appearance rates

Endogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).

Time frame: 120 minutes

Glucose clearance rates

Glucose clearance rates following an oral glucose tolerance test (total clearance over 120 minutes).

Time frame: 120 minutes

Energy intake

Weighted energy intake over 24 hours from the beginning of the trial.

Time frame: 24 h

Energy expenditure

Energy expenditure, derived from indirect calorimetry, acccelerometry and heart rate monitoring.

Time frame: 24 h

Exogenous glucose appearance rates

Exogenous glucose appearance rates following an oral glucose tolerance test (total appearance over 120 minutes).

Time frame: 120 minutes

Exercise in the Fasted State, Glucose Metabolism and Energy Balance

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes