The main purpose of this study is to evaluate the efficacy and safety of the study drug known as evacetrapib in Japanese participants with primary hypercholesterolemia. The double blind treatment period will last for 12 weeks and the open-label extension period will last for an additional 40 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
54
Administered orally
Administered orally
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Osaka, Japan
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Tokyo, Japan
Percent Change From Baseline to Week 12 in Low-Density Lipoprotein Cholesterol (LDL-C) Measured by Beta Quantification
Least Square Mean (LS mean) using mixed model repeated measures (MMRM) adjusted for baseline, treatment, visit , and treatment\*visit, where the participant is a random effect.
Time frame: Baseline, Week 12
Percent Change From Baseline in High-Density Lipoprotein Cholesterol (HDL-C)
LS mean using MMRM adjusted for baseline, treatment, visit , and treatment\*visit, where the participant is a random effect.
Time frame: Baseline, Week 12
Percent Change From Baseline in LDL-C (Direct)
LS mean using MMRM adjusted for baseline, treatment, visit , and treatment\*visit, where the participant is a random effect.
Time frame: Baseline, Week 12
Percent Change From Baseline in Non HDL-C
LS mean using MMRM adjusted for baseline, treatment, visit , and treatment\*visit, where the participant is a random effect.
Time frame: Baseline, Week 12
Percent Change From Baseline in Lipoprotein-a
LS Mean from analysis of covariance (ANCOVA) model adjusted for baseline and treatment.
Time frame: Baseline, Week 12, Week 52
Percent Change From Baseline in Apolipoprotein A-I
LS Mean from ANCOVA model adjusted for baseline and treatment.
Time frame: Baseline, Week 12, Week 52
Percent Change From Baseline in Apolipoprotein B
LS Mean from ANCOVA model adjusted for baseline and treatment.
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Time frame: Baseline, Week 12, Week 52