Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST

CRPS-patients Inclusion Criteria: * Unilateral pain on the upper limbs, based on a scintigraphic ensured CRPS (average pain in the last 4 weeks ≥ 3 in pain Detect) * Pain history \< 1 year Exclusion criteria: * Bilateral pain on the upper limbs * Inadequate knowledge of the german language in speaking and writing * Acute psychiatric sickness * Polyneuropathy * Any added neuropathic sickness on the not affected upper limb sight * Intolerable pain during the testing * Injuries within the tested areal * Acute injuries on the hand * Pregnancy * Missing informed consent CTS-patients Inclusion Criteria: * Unilateral pain on the upper limbs, based on a scintigraphic ensured CRPS (average pain in the last 4 weeks ≥ 3 in pain Detect) * Pain history \< 1 year Exclusion criteria: * Bilateral pain on the upper limbs * Inadequate knowledge of the german language in speaking and writing * Acute psychiatric sickness * Polyneuropathy * Any added neuropathic sickness on the not affected upper limb sight * Intolerable pain during the testing * Injuries within the tested areal * Acute injuries on the hand * Pregnancy * Missing informed consent Healthy subjects Inclusion Criteria: * Age \> 18 years * Written consent Exclusion criteria: * Inadequate knowledge of the german language in speaking and writing * Current pain * Pain within in the last 14 days * Any serious internistic medicin * Any chronic skin disease * Any central neural sickness * Polyneuropathy * Peripheral nerve lesion within the testing areal * Any radiculopathy with permanent pain (in the last 3 months) * Any psychiatric sickness * Migraine ( at least one attack in the last 24 h) * Repeating headache (in the last 3 month on \>5 days/month) * Taking any analgesics in the last 14 days * Taking triptans in the last 24 months * Taking any psychotropic's in the last 3 months * Any repeated taking of medication, including amber or different psychostimulants (excluding contraceptives) * Taking of any prescription and non-prescription drugs (except contraceptives) in the last 7 days or 5 half-life periods(which is always longer) before including into the study * Achilles reflex absent or within in the side-difference pathologic hypoactive or hyperactive * pallaesthesia \<5/8 (\<4/8 at \>60 years) on the internal malleolus on both sides * abuse of alcohol or medications/drugs (corresponding to the DSM IV criteria) * joining a medical study \<30 days before inclusion into the current study * jet lag, irregular work schedule, sleep deprivation within the last 3 days * change of intestity during physical activity, e.g. beginning an activity in the last weeks before inclusion into the current study