Dysfunctional Hemoglobin

Inclusion Criteria: * Subjects does not have significant medical problems * Subject is willing to provide written informed consent * Subject is between 18 and 45 years of age Exclusion Criteria: * Has a BMI greater than 31 * Has had any relevant injury at the sensor location site * Has deformities or abnormalities that may prevent proper application of the device under test * Has a known respiratory condition * Is currently a smoker * Has a known heart or cardiovascular condition * Is currently pregnant * Is female and actively trying to get pregnant * Has a clotting disorder * Is known to have a hemoglobinopathy such as (anemia, bilirubinemia, sickle-cell anemia, inherited or congenital methemoglobinemia) * The subject has a COHb greater than 3% or MetHb greater than 2% * Has taken blood thinners or medication with aspirin within the last 24 hours * Has unacceptable collateral circulation from the ulnar artery * Has donated more than 300 mL of blood within one month prior to start of study * Is unwilling or unable to provide written informed consent to participate in the study * Is unwilling or unable to comply with the study procedures * Has another health condition which in the opinion of the principal investigator makes him/her unsuitable for testing