The Efficacy and Safety of Nab-paclitaxel in Pretreated Patients With Extensive Disease of Small Cell Lung Cancer

Inclusion Criteria: 1. Obtain of informed consent. 2. Male or female aged 18 years and over. 3. Histologically or cytologically confirmed small cell lung carcinoma. 4. Extensive disease before receive nab-paclitaxel. 5. Failed to previous chemotherapy, but the previous paclitaxel chemotherapy is not allowed. 6. World Health Organization (WHO) performance status (PS) of 0 to 2. 7. Females of child-bearing potential must have negative serum pregnancy test. Sexually active males and females (of childbearing potential) willing to practice contraception during the study. 8. Heart index values is in the range, as defined below, within two weeks of randomization: * Absolute neutrophils count(ANC)≥2.0×109/L * Platelets≥100×109/L * Serum bilirubin≤2×ULN; Aspartate transaminase(AST) and alanine transaminase (ALT) ≤2.5×ULN(≤5×ULN if liver metastases) * Creatinine clearance≥60ml/min 9. Measurable disease according to Response Evaluation Criteria in Solid Tumors(RECIST) criteria with at least one measurable lesion not previously irradiated. 10. Life expectancy ≥12 weeks. Exclusion Criteria: 1. As judged by the investigator, any evidence of severe or uncontrolled systemic disease (e.g. unstable or uncompensated respiratory, cardiac, hepatic or renal disease). 2. Newly diagnosed Central Nervous System (CNS) metastases that have not yet been definitively treated with surgery and/or radiation. 3. Known severe hypersensitivity to nab-paclitaxel or any of the excipients of these products.Known severe hypersensitivity to pre-medications required for treatment with nab-paclitaxel doublet chemotherapy. 4. Prior treatment with paclitaxel. 5. Pregnant or lactating woman. 6. Other co-existing malignancies or malignancies diagnosed within the last 5 years with the exception of basal cell carcinoma or cervical cancer in situ. 7. Life expectancy of less than 12 weeks.