Evaluation of a Human Acellular Dermal Matrix in Post Mastectomy Reconstruction

Inclusion Criteria: * Scheduled to undergo a single or two-stage, tissue-assisted, implant breast reconstruction * Mastectomy may be unilateral or bilateral, prophylactic or therapeutic * Skin incision may be skin sparing, or nipple-areolar sparing * Have signed written, informed consent * Be at least 18 years of age Exclusion Criteria: * Patients undergoing autologous breast reconstruction * Patients undergoing breast reconstruction following complications of breast augmentation, mastopexy, breast reduction, or breast conservation surgery (lumpectomy) * Patients undergoing reconstruction after previously failed attempts at reconstruction * Patients undergoing autologous breast reconstruction in conjunction with a tissue expander (such as a latissimus dorsi flap, DIEP flap) * There will be no exclusions based on race or ethnicity * BMI \> 40 * Previous Radiation Treatment. Note: Post-operative radiation treatment does not exclude subjects from study continuation once enrolled.