Increasing Dose Study of Pramipexole in Two-way Cross-over Comparison of ER Tablet Versus IR Tablet in Japanese Healthy Male Volunteers

Inclusion Criteria: * All subjects participating in the study are healthy male volunteers * Age between 20 and 40 years * Body mass index (BMI) between 17.6 and 26.4 kg/m2 * All volunteers must give written informed consent before screening to participate in this study and before first drug administration on Day 1 at Visit 2 Exclusion Criteria: * Any findings of the medical examination (including blood pressure, pulse rate, ECG, and laboratory test parameters) of clinical relevance * Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * Diseases of the central nervous system (such as epilepsy), psychiatric disorders or neurological disorders * History of orthostatic hypotension, fainting spells or blackouts * Chronic or acute infections * History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * Intake of drugs with a long half-life (\>24 hours) within at least one month or less than ten half-lives of the respective drug before the administration of investigational products * Use of any drugs which might influence the results of the trial within 7 days before the start of drug administration in the study or during the study period * Participation in another trial with an investigational drug (within 4 months before the start of drug administration) * Smoker (\>10 cigarettes or \>3 cigars or \>3 pipes/day and who cannot refrain from smoking at the trial site) * Alcohol abuse (\>40 g/day) * Drug abuse * Blood donation (≥100 mL within 4 weeks before drug administration or during the trial) * Excessive physical activities from 7 days before the start of drug administration to the end of this study * Any positive results in hepatitis B surface antigen (HBsAg), anti hepatitis B core (HBc) antibodies, anti hepatitis C virus (HCV) antibodies and human immunodeficiency virus (HIV) test The following exclusion criteria are of special interest for this study: * Hypersensitivity to pramipexole or other dopamine agonists * Supine blood pressure at screening of systolic \<110 mmHg and diastolic \<60 mmHg