Influence of Telmisartan and Lacidipine, Combined or Alone, on QT Interval in Healthy Volunteers

Inclusion Criteria: All participants in the study should be healthy males/females, range from 21 to 50 years of age and their body mass index (BMI) be within 18.5 to 29.9 kg/m2. In accordance with Good Clinical Practice and local legislation all volunteers will have given their written informed consent prior to admission to the study. Exclusion Criteria: * Any finding of the medical examination (including blood pressure, heart rate and ECG) deviating from normal and of clinical relevance * Gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * Diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders * History of orthostatic hypotension, fainting spells or blackouts * Chronic or relevant acute infections * History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * Intake of drugs with a long half-life (\>24 hours) within at least one month or less than ten half-lives of the respective drug before enrolment in the study or during the study * Use of any drugs which might influence the results of the trial up to 7 days prior to enrolment in the study or during the study * Participation in another tiral with an investigational drug (\<= two months prior to administration or during the trial) * Smoker (\> 10 cigarettes or \> 3 cigars or \> 3 pipes/day) * Inability to refrain from smoking on trial days * Alcohol abuse (\> 60 g/day) * Drug abuse * Blood donation (\>= 100 ml within four weeks prior to administration or during the trial) * Any laboratory value outside the clinically accepted reference range * Excessive physical activities within the last week before the trial or during the trial Following exclusion criteria are of special interest for this study: * Hypersensitivity to telmisartan, lacidipine and/or related drugs of these classes * Supine blood pressure at screening of systolic \<= 110 mmHg and diastolic \<= 60 mmHg * Any ECG value outside of the reference range of clinical relevance, but not limited to PR interval \> 240 ms, QRS interval \> 110 ms, QTcB \> 470 ms for females and QTcB \> 450 ms for males For female subjects: * Pregnancy * Positive pregnancy test * No adequate contraception (adequate contraception e.g. sterilisation, intrauterine pessary (IUP), oral contraceptives) * Inability to maintain this adequate contraception during the whole study period * Lactation period