Oral Verses Patch Trial In Menopausal Women - Individualisation of Oestrogen Therapy

Inclusion Criteria: * Healthy and postmenopausal woman who have had a normal ultrasound result * Aged 40 - 60 years * At least 1 year post last menstrual period (per participant report) * BMI 18 - 32 * Normal mammogram within 2 years of study commencement * Continue on any concomitant medications without any change during the study give informed consent Exclusion Criteria: * Estrogen or androgen therapy during preceding 3 months * Use of hormone implants during the preceding 12 months * Have received any medications which may interfere with the study (SSRI, antiandrogens, * PDE5 inhibitors, DHEA, SERMS) * Have a significant psychiatric disorder * Have a history of breast or oestrogen dependent cancer * Have diabetes, thrombo-embolic disorders (recent MI angina DVT varicose veins or recurrent DVT), cardiovascular disease, liver disease any condition affecting carbohydrate metabolism, uncontrolled hypertension and uncontrolled hyperlipidaemia * Untreated endometrial hyperplasia * Dubin-Johnson syndrome and Rotor syndrome * Undiagnosed vaginal bleeding * Women who have had a hysterectomy