Safety, Tolerability, Biological Effects and Pharmacokinetics of BIIL 284 BS in Healthy Males

Inclusion Criteria: * Healthy male subjects as determined by results of screening * Age ≥ 21 and ≤ 50 years * Broca ≥ - 20% and ≤ + 20% * Signed written informed consent in accordance with Good Clinical Practice and local legislation Exclusion Criteria: * Results of the medical examination or laboratory tests that are judged by the clinical investigator to differ significantly from normal clinical values * Known gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * Diseases of the central nervous system (such as epilepsy) or with psychiatric disorders * Known history of orthostatic hypotension, fainting spells or blackouts * Chronic or relevant acute infections * History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * Intake of a drug with a long half-life (≥ 24 hours) within at least one month or less than ten half-lives of the respective drug before enrolment in the study * Intake of any other drugs which might influence the results of the trial during the week previous to the start of the study * Participation in another study with an investigational drug within the last two months preceding this study * Smokers (\> 5 cigarettes or 2 cigars or 2 pipes/day) * Volunteer who is not able to refrain from smoking on study days * Alcohol abuse (more than 60 g of alcohol per day) * Drug abuse * Excessive physical activities (e.g. competitive sports) within the last week before the study * Blood donation within the last 4 weeks (≥ 100 ml)