Phase Ⅱ Dose Response Study of NPO-13 in Patients Undergoing Total Colonoscopy

Inclusion Criteria: Inpatients or outpatients of either sex who visit medical institutions for treatment or follow-up of confirmed or suspected colonic disease (symptoms) and meet the criteria (1) and (2) below will be enrolled in the study. Patients have to provide written informed consent for voluntary participation in the study. 1. Patients who need colonoscopy 2. Patients who are older than 20 years at the time of consent Exclusion Criteria: 1. Patients with a history of abdominal surgical treatment (including the laparoscopic surgery) including the gynecology operation 2. Patients with contraindication to colonoscopy including the paralytic ileus 3. Patients with a history of shock or hypersensitivity to l-menthol or peppermint oil (mint oil) 4. Patient with contraindication to bowel cleansing preparation 5. Patients on cancer treatment (chemotherapy or radiotherapy) 6. Patients who need sedative colonoscopy 7. Patients who receives a therapeutic colonoscopy 8. Pregnant or lactating women, women of childbearing potential, or women who plan to become pregnant during the study 9. Patients who have received other investigational drugs within four months before consent or who are participating in other clinical studies 10. Patients who have been exposed to NPO-13 11. Patients otherwise ineligible for participation in the study in the investigator's or subinvestigator's opinion