This study will evaluate the effects of transcranial direct current stimulation (tDCS) in combination with locomotor training in patients with Parkinson's disease (PD) and freezing of gait (FOG).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
9
Anodal tDCS will be applied for the duration of the walking training at 2 milliamps with IOMED Phoresor.
An individualized dual-task walking program for approximately 30 minutes.
University of Miami
Miami, Florida, United States
Change in Walking Speed
walking speed will be measured using sensors during a 90 second walk
Time frame: baseline, 3 weeks
Change in Motor Scores as Measured by Unified Parkinson's Disease Rating Scale (UPDRS)
UPDRS motor score range from 0-56 with higher scores indicating greater impairment.
Time frame: baseline, 3 weeks
Change in Stride Length
Stride length is measured with mobile sensors attached to participant's extremities during the 90 second walk.
Time frame: baseline, 3 weeks
Change in Postural Sway
Postural sway is measured with mobile sensors attached to participant's extremities during the 30 seconds of quiet standing.
Time frame: baseline, 3 weeks
Change in Timed Up-and-Go (TUG) Time
Participants are timed while standing up from a chair, walking around a cone, and returning to their chair.
Time frame: baseline, 3 weeks
Change in Motor Threshold
Transcranial magnetic stimulation is used to measure motor threshold of the primary motor area. The motor threshold was defined as the minimum intensity needed to evoke 5 out 10 motor evoked potentials in the first dorsal interosseous muscle in the hand.
Time frame: baseline, 3 weeks
Change in Glutamate/Gamma Aminobutyric Acid(GABA) Ratio
Glutamate/GABA ratio will be measured with magnetic Resonance Spectroscopy (MRS).
Time frame: baseline, 3 weeks
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Change in Backward Digit Span
Digit span is measured by total number of correct digits recited.
Time frame: baseline, 3 weeks
Change in the Trail Making Test Time
Trail making test is measured as the number of seconds required to complete the task, with higher scores indicating greater impairment.
Time frame: baseline, 3 weeks
Change in the Montreal Cognitive Assessment (MOCA)
The MOCA has a total score ranging from 0-30 with a higher score indicating better performance.
Time frame: baseline, 3 weeks
Change in the Auditory Consonant Trigrams Test (ACT)
The ACT has a score from 0-60 with higher score indicating better performance.
Time frame: baseline, 3 weeks
Change in the Freezing of Gait Questionnaire (FOG-Q)
The FOG-Q has a total score ranging from 0-24 with higher scores indicating more incidents of freezing.
Time frame: baseline, 3 weeks