The purpose of this study is to compare hyperglycemia and other effects, include 28-day mortality and time to reversal of shock between 100 milligrams and 200 milligrams of hydrocortisone as initial dosage in patients with septic shock.
The intervention group will be received 100 milligrams per day of hydrocortisone on the first three day the taper off, whereas the control group will be received 200 milligrams per day of hydrocortisone on the first three day the taper off. Hyperglycemia rate will be monitored every 6 hours after hydrocortisone is started until 24 hours after it is stopped. Also, 28-day mortality will be follow after hydrocortisone is started.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
Subjects will be divided into two groups by randomization. The intervention-group will be received 100 milligrams per day of hydrocortisone and the control-group will be received 200 milligrams per day of hydrocortisone in the first three days after enrollment.
Department of Medicine, Faculty of Medicine, Srinakharinwirot University
Ongkharak, Changwat Nakhon Nayok, Thailand
Hyperglycemia
Proportion of hyperglycemic patients
Time frame: two years
28-day mortality
The number of the patients who died before or at 28 days after enrollment.
Time frame: two years
Time to shock reversal
The dates when vasopressors can be stopped.
Time frame: two years
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