Role of Omalizumab in Reducing the Incidence of Oxaliplatin-induced Hypersensitivity Reaction

Inclusion Criteria: * Clinically evident HSR to oxaliplatin, with symptoms of flushing, urticaria, pruritus, rash, and/or dyspnea without bronchospasm that emerge during or shortly after of oxaliplatin infusion * Responding (complete or partial) or stable disease according to RECIST criteria while undergoing treatment with oxaliplatin containing regimen or need to resume an oxaliplatin based regimen in the setting of well-documented recent oxaliplatin hypersensitivity reaction * Histologically confirmed stage IV GI cancer (AJCC 7th edition) currently sensitive to oxaliplatin containing chemotherapy regimen * Age 18 years or older * ECOG performance status 0-2 * Adequate bone marrow, liver, and kidney function. (WBC \> 1500 cells/uL, platelets \> 50,000/uL, ALT/AST \< 5xULN (unless due to liver metastasis), Creatinine \< 2.0 mg/ld) * Willing to give written informed consent, adhere to the visit schedules and meet study requirements Exclusion Criteria: * Prior history of severe reactions to oxaliplatin as characterized by the presence of hemodynamic instability, significant respiratory symptoms or potential airway compromise * History of hypersensitivity reaction to Xolair or any ingredient of Xolair * Concurrent therapy with investigational agents * Use of any other investigational agent in the last 15 days and all toxicity of prior therapy resolved * Psychological, familial, or sociological condition potentially hampering compliance with the study protocol and follow-up schedule * Women of childbearing potential not using the contraception method(s), as well as women who are breastfeeding * Patients with severe medical conditions that in the view of the investigator prohibits participation in the study