Magnetic Resonance Elastography of Cardiac Transplant Rejection

Ohio State University9 enrolled

Overview

Magnetic Resonance Elastography (MRE) for cardiac transplant patients.

Patient will undergo MRE beginning 4-8 weeks post transplant, then with each scheduled cardiac biopsy through 7-8 months post transplant. Results of the MRE will be compared against results of the cardiac biopsy to determine if the non-invasive MRE can predict cardiac transplant rejection.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Acute Graft Rejection

Interventions

Magnetic Resonance Elastography driverDEVICE

A driver is required for MRE. The driver utilizes sound waves to produce vibrations. Images of these vibrations are captured with Magnetic Resonance scanner to produce images that indicate stiffness in an organ.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients must have undergone cardiac transplantation at the Ohio State University Ross Heart Hospital. * Patients must be able to lie flat on their back in the scanner for up to 60 minutes * Patient must be able to hold their breath for up to 15 seconds at a time. Exclusion Criteria: * Patients who are claustrophobic * Patients who are pregnant, due to potential risks to the fetus. * Patients with any unapproved, non-MRI safe metal/devices in their bodies.

Locations (1)

The Ohio State University Medical Center

Columbus, Ohio, United States

Outcomes

Primary Outcomes

Cardiac Stiffness With Magnetic Resonance Elastography (MRE)

MRE scans will be performed within 24-48 hours of standard of care cardiac biopsies for patients who have undergone cardiac transplant at The Ohio State University Ross Heart Hospital. Stiffness results from the MRE will be compared to histopathology from the cardiac biopsy to determine if the completely non-invasive MRE can successfully predict transplant rejection.

Time frame: 24-48 hours

Data from ClinicalTrials.gov

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