The purpose of this study is to analyse the sensitivity and specificity of circulating endothelial cells to predict irreversible pulmonary arterial hypertension associated with congenital heart disease.
predict to recruit 100 patients with pulmonary arterial hypertension (PAH)associated with CHD，under the commitment of the children's parents，take 3-4ml central venous blood before the corrective surgery，then calculate the number of the circulating endothelial cells by flow cytometer AND detect the expression of micro RNAs to screen out the biomarker，through the 6 months follow-up, separated the reversible and irreversible PAH,then to carry on the statistics.
Study Type
OBSERVATIONAL
Enrollment
30
Shanghai Children's Medical Center
Shanghai, Shanghai Municipality, China
the number of Circulation endothelial cells and the detective count of microRNAs
the number of Circulation endothelial cells and the detective count of microRNAs in the biomarkers in both groups differd significantly.
Time frame: 6 months after corrective surgery
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