Open Label Trial of Rapastinel (Formerly GLYX-13) in Individuals With Obsessive-Compulsive Disorder

Inclusion Criteria for Patients with No medication Washout: * Age 18-55 * Physically healthy and not currently pregnant * Primary Diagnosis of OCD * currently off all psychotropic medications and other drugs * Able to provide informed consent Exclusion Criteria for Patients with No Medication Washout: * Psychiatric conditions that make participation unsafe (schizophrenia \[either self or first degree relative e.g. siblings, parents\], history of violence, severe depression, eating disorder, substance abuse in prior year\[including nicotine\], lifetime substance dependence disorder \[except nicotine\]) * Female patients who are either pregnant or nursing * Enrolled in or planning to enroll in Cognitive Behavioral Therapy. * Medical conditions that make participation unsafe (e.g., high blood pressure, head injury) * Currently on medications that make participation unsafe * History of allergy, sensitivity, or intolerance to N-methyl-D-aspartate receptor (NMDAR) ligands including ketamine, dextromethorphan, memantine, methadone, dextropropoxyphene, or ketobemidone. Inclusion Criteria for Patients with Medication Washout: * Age 18-55 * Physically healthy and not currently pregnant * Primary Diagnosis of OCD * Currently on adequate dose of medication for treatment of OCD, but have not achieved at least partial remission and able to handle a medication washout. * Able to provide informed consent Exclusion Criteria for Patients with Medication Washout: * Psychiatric conditions that make participation unsafe (schizophrenia \[either self or first degree relative e.g. siblings, parents\], history of violence, severe depression, eating disorder, substance abuse in prior year\[including nicotine\], lifetime substance dependence disorder \[except nicotine\]) * Female patients who are either pregnant or nursing * Enrolled in or planning to enroll in Cognitive-Behavioral Therapy. * Patient judged unlikely to be able to tolerated a medication washout. * Medical conditions that make participation unsafe (e.g., high blood pressure, head injury) * Currently on medications that make participation unsafe * History of allergy, sensitivity, or intolerance to N-methyl-D-aspartate receptor (NMDAR) ligands including ketamine, dextromethorphan, memantine, methadone, dextropropoxyphene, or ketobemidone.