The investigators evaluate the effects of a subanesthetic dose of ketamine, administered as an adjunct to sevoflurane, on duration of seizure activity, hemodynamic profile and recovery times during electroconvulsive therapy (ECT) in patients with major depression.
Patients will randomly allocate, to either a sevoflurane-ketamine (Group SK), sevoflurane-saline (Group SS) receiving group. Mean arterial pressure (MAP) and heart rate (HR) will record prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively). Motor and EEG seizure durations will be recorded.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Inhalation anesthetic agent
Intravenous anesthetic agent
Isotonic solution for placebo group
Turgut Ozal Medical Center
Malatya, Turkey (Türkiye)
RECRUITINGseizure duration
the time from application of the ECT stimulus to the cessation of tonic-clonic motor activity in the isolated arm.
Time frame: During electroconvulsive therapy (30 minutes)
Mean arterial pressure (MAP)
Mean arterial pressure (MAP) will be recorded prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively).
Time frame: During Electroconvulsive therapy (30 minutes)
Heart rate (HR)
Heart rate (HR) will be recorded prior to anesthetic induction (T1); following anesthetic induction (T2); and 0, 1, 3, and 10 min after the seizure has ended (T3, T4, T5, and T6, respectively).
Time frame: During Electroconvulsive therapy (30 minutes)
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