Diagnosis of Individuals With Pulmonary Nodules by Different Bronchoscopy Combination

Inclusion Criteria: * Eligible subjects are adults with solitary peripheral pulmonary lesions (mean diameter, ≤30mm and \>8mm from axial CT images) suspected to be cancer but were not pathologically confirmed. Exclusion Criteria: * Patient has dysrhythmia or cardiovascular disease that poses a risk during exercise. * Patient has uncontrollable hypertension (SBP \> 180mmHg). * Patient has severe organ dysfunction (shock, severe hepatic and renal dysfunction, massive hemorrhage of upper gastrointestine, diffuse intravascular coagulation(DIC) and massive hemoptysis,etc). * Patient has blood coagulation disorders (PT\>2 times the upper limit of normal(ULN) or Platelet(PLT)\<50000/ul）. * Patient has severe dyspnea. * Patient is allergic to local anesthetic. * Patient is unable to provide informed consent. * Patient is not an appropriate candidate for of is unable to tolerate flexible bronchoscopy procedures. * Patient has any disease or condition that interferes with completion of initial or follow-up assessments of the effectiveness endpoints. * Patient has demonstrated unwillingness or inability to complete screening or baseline data collection procedures. * Patient participated in a study of an investigational drug or device within the past 30 days prior to participation in this study, or is currently participating in another clinical study. * Female patient of childbearing potential has a positive result from a pregnancy test.