This pilot study is designed to test the effects of a high legume (dried bean) diet on hunger and other indicators of health over the course of eight weeks, compared to a more conventional healthy diet.
The goal of the currently proposed study is to conduct a randomized controlled feeding pilot study within a more diverse population also at high risk for colorectal carcinoma (CRC) to evaluate whether a high-legume diet will result in increased satiety and in turn will facilitate reduced energy intake and weight loss compared to a control diet provided under similar conditions. In addition, explore potential beneficial effects of the high-legume diet on gastric emptying and circulating levels of appetite-regulating hormones and other biomarkers. Dietary behaviors that are even moderately more satiating over time have the potential to enhance weight loss and could lead to a significant public health impact among populations at high risk for colorectal carcinoma (CRC) and other chronic diseases. Towards the end of the study, the participants will do an additional test, looking at how long food takes to pass through the digestive system using a SmartPill capsule. The SmartPill is a pill about the size of a large multivitamin that can measure pH, pressure, and temperature changes, which it uses to assess where in the digestive tract it is. The participant swallows the pill, and carries around a receiver that is about the size of a deck of cards for the next 3-5 days. The SmartPill is expelled, and the receiver notifies the participant that they can return the receiver to the study personnel.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
12
about 1 1/2 cups of legumes included in lunch and dinner meals
no legumes in lunch or dinner meals
to assess how long food takes to pass through the digestive system
Morehouse
Atlanta, Georgia, United States
Emory ACTSI
Atlanta, Georgia, United States
Change in Weight
Evaluate the effects of a high-legume diet compared to a control diet with a similar macronutrient profile on weight change in a randomized controlled feeding study.
Time frame: Baseline to 8 weeks
Gastric Emptying Time
Compare the effects of the high-legume and control diets on gastric emptying time
Time frame: 8 weeks
Change in Plasma Insulin Level (Biomarker of Appetite Regulation)
Compare the effects of the high-legume and control diets on plasma insulin level in a meal response time (30 min) course experiment.
Time frame: Baseline to 8 weeks
Energy Intake
Compare the effects of the high-legume and control diets on self-reported dietary intake measured by telephone 24-hour dietary recalls.
Time frame: Baseline to 8 weeks
Satiety
Use self-reported satiety questionnaire to compare short-term responses to test meals.
Time frame: Time course response at baseline and 8 weeks
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about 1 1/2 cups of legumes included in lunch and dinner meals