The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast Cancer Patients

Inclusion Criteria: * Elective breast surgery due to breast cancer * Voluntary * BMI ≥ 18 and ≤ 35 kg/m2 * ASA 1-3 * No regular use of beta-blockers or during the last 72 hours * No contraindications to beta-blockers Exclusion Criteria: * Pregnancy or breast feeding * AV-block, degree II or III * Untreated cardiac insufficiency * Sinus bradycardia, heart rate \< 45 / min or symptoms * Sick sinus syndrome * Cardiogenic shock * Severe peripheral vascular disorder * Systolic blood pressure \< 100 mmHg * Long PQ-time, \> 0,24 seconds * Known hypersensitivity to beta-blockers or the ingredients of the drug