Enhanced Diagnostics for Early Detection of Atrial Fibrillation

University Hospital, Basel, Switzerland287 enrolled

Overview

Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present. The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.

In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens. Parameters tested are 1. Electrophysiological differences between patients with paroxysmal AF and no history of AF 2. "Vascular Stiffness" detected by an iPhone app All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.

Study Type

OBSERVATIONAL

Enrollment

287

Conditions

Atrial Fibrillation

Interventions

ECGDEVICE

Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * paroxysmal atrial fibrillation in sinus rhythm at presentation Exclusion Criteria: * acute cerebral trauma * antiarrhythmic medication

Locations (1)

University Hospital Basel

Basel, Canton of Basel-City, Switzerland

Outcomes

Primary Outcomes

Beat to beat variation of the electrical activation vector of the atrium

Test if the beat to beat Variation of the electrical activation of the atrium differentiates between the group of patients with paroxysmal AF and no AF in history.

Time frame: Once during the exam (baseline) - No further follow up planned

Secondary Outcomes

Averaged slope of pressure-curve

Test if the steepness of the slope of the pressure curve recorded with the iPhone differs between the two Groups.

Time frame: Once during exam (5min, baseline) - No further follow up planned

Averaged slope of pressure-curve

Test if the steepness of the slope of the pressure curve recorded with the iPhone correlates with cardiovascular risk factors.

Time frame: Once during exam (5min, baseline) - No further follow up planned

Heart rate variability

Test if heart rate variability recorded with the iPhone differs between the two Groups.

Time frame: Once during exam (5min, baseline) - No further follow up planned

Data from ClinicalTrials.gov

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