Respiratory muscle weakness results with decreased exercise capacity, worse fatigue, dyspnea and quality of life in patients with sarcoidosis. However, no study investigated the effects of inspiratory muscle training (IMT), therefore effects of IMT on outcomes in patients with sarcoidosis were investigated.
Patients were diagnosed with sarcoidosis according to the criteria of the latest American Thoracic Society (ATS)/European Respiratory Society (ERS)/World Association of Sarcoidosis and Other Granulomatous (WASOG) Disorders statement on sarcoidosis. Primary outcome measurement was respiratory muscle strength, secondary outcomes were, exercise capacity quality of life, fatigue and depression.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Enrollment
30
Treatment group received inspiratory muscle training (IMT) using threshold loading device (POWERbreathe Classic, IMT Technologies Ltd. Birmingham, England) at 40% of maximal inspiratory pressure (MIP). The MIP was measured at supervised session each week, and 40% of measured MIP value was the new training workload. The treatment group trained for 30 min-per/day, 7 days/week, for 6 weeks. Six sessions at home and 1 session were performed at department.
Control group received sham inspiratory muscle training (IMT) at fixed workload, 5% of MIP using threshold loading device (POWERbreathe Classic device IMT Technologies Ltd. Birmingham, England). The control group trained for 30 min-per/day, 7 days/week, for 6 weeks. Six sessions at home and 1 session were performed at department.
Maximum inspiratory and expiratory muscle strength (MIP, MEP)
Mouth pressure device
Time frame: 6 weeks
Exercise Capacity
Six-minute walk test (6MWT)
Time frame: 6 weeks
Maximal Exercise Capacity
Modified incremental shuttle walk test (ISWT)
Time frame: 6 weeks
Fatigue
Fatigue Severity Scale (FSS)
Time frame: 6 weeks
Pulmonary function and diffusing capacity
Spirometry
Time frame: 6 weeks
Peripheral muscle strength
Hand-held dynamometer
Time frame: 6 weeks
Dyspnea
Modified Borg and Modified Medical Research Council (MMRC) dyspnea scales
Time frame: 6 weeks
Depression
Montgomery Asberg Depression Rating Scale (MADRS))
Time frame: 6 weeks
Quality of life
Saint George's Respiratory Questionnaire (SGRQ) (Turkish versions of all scales)
Time frame: 6 weeks
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