This partially randomized clinical trial studies surgery or non-surgical management in treating patients with intra-abdominal cancer and bowel obstruction. Bowel obstruction is a common problem for advanced cancer patients and can negatively affect quality of life. It is not yet known whether surgery or non-surgical management is the best treatment option for bowel obstruction and can lead to better quality of life.
This partially randomized clinical trial studies surgery or non-surgical management in treating patients with intra-abdominal cancer and bowel obstruction. Bowel obstruction is a common problem for advanced cancer patients and can negatively affect quality of life. It is not yet known whether surgery or non-surgical management is the best treatment option for bowel obstruction and can lead to better quality of life.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
221
Undergo abdominal surgery
Undergo non-surgical management
Ancillary studies
Cancer Center at Saint Joseph's
Phoenix, Arizona, United States
Banner University Medical Center - Tucson
Tucson, Arizona, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Loma Linda University Medical Center
Loma Linda, California, United States
Number of Days Alive and Outside of the Hospital
Number of days alive and outside of the hospital
Time frame: From date of registration up to 91 days
Number of Days in Hospital
Length of initial hospital stay in days.
Time frame: During initial hospitalization, from date of registration to a maximum of 53 weeks post registration
NG Tube Use
Use of a nasogastric tube
Time frame: During initial hospitalization, from date of registration to a maximum of 53 weeks post registration
Days of NG Tube Use
Number of days a nasogastric tube was used during the patient's initial hospitalization
Time frame: During entire initial hospitalization (admission to discharge) to a maximum of 53 weeks post registration
MDASI-GI Symptom Assessment
The MD Anderson Symptom Inventory for gastrointestinal cancer (MDASI-GI) was used to assess nausea, vomiting, pain, bloating, and constipation. The MDASI measures symptom severity on an 11-point scale, from 0 ("not present") to 10 ("as bad as you can imagine"). A difference of at least 1.2 points was considered a clinically meaningful difference between groups for MDASI-GI outcomes.
Time frame: Assessed at 4 weeks post registration
Ability to Eat
Ability to consume food was assessed based on self or caregiver-reported 24-hour dietary recalls. Dietary recalls were collected by trained assessors at the University of Arizona Cancer Center Behavioral Measurement and Interventions Shared Resource (BMISR) via telephone using standardized protocols and Nutrient Database for Research.
Time frame: Assessed at 5 weeks post registration
Overall Survival
Time from date of registration to date of death due to any cause.
Time frame: From date of registration to maximum of 53 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Moffitt Cancer Center
Tampa, Florida, United States
Rush University Medical Center
Chicago, Illinois, United States
University of Kansas Cancer Center
Kansas City, Kansas, United States
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
...and 28 more locations