Morbidity in Patients With Hypertension and Obstructive Sleep Apnea

University of Sao Paulo General Hospital123 enrolled

Overview

MORPHEOS is a multicenter, randomized, unblinded study, for patients diagnosed with uncontrolled hypertension and at least one antihypertensive medication. Those patients with significant sleep apnea wil be randomized to CPAP or nasal strips for 6 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

123

Conditions

Hypertension Sleep Apnea, Obstructive

Interventions

CPAPDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥ 90 mm Hg * Current treatment with at least 1 antihypertensive drug Exclusion Criteria: * Age \<18 and \>65 years * BMI ≥ 40 kg/m2 * Heart failure, EF \< 45%, acute myocardial infarction, stroke, significant valvular dysfunction * Chronic renal failure (serum creatinine \> 2 mg/dL) * Use of cocaine, amphetamines, alcohol, illicit drugs * Use of sympathomimetics (decongestants, appetite suppressants) * Use of oral contraceptives and chronic use of NSAIDs * Pregnancy * Secondary causes of hypertension (other than sleep apnea)

Locations (5)

Pronto Socorro Cardiológico de Pernambuco (PROCAPE)

Recife, Pernambuco, Brazil

Hospital das Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto

Ribeirão Preto, São Paulo, Brazil

Fundação Zerbini - Instituto do Coração (InCor)

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Impact of OSA treatment with CPAP on office, 24-hour, and central blood pressure (co-primary endpoints).

Time frame: 6 months

Secondary Outcomes

Impact of OSA treatment with CPAP on target-organ damage

Time frame: 6 months

Impact of OSA treatment with CPAP on vascular parameters (to be published as a sub-study)

Pulse wave velocity and carotid intima-media thickness

Time frame: 6 months

Impact of OSA treatment with CPAP on hypertensive retinopathy and optic nerve damage (to be published as a sub-study)

Time frame: 6 months

Validation of portable sleep monitoring to diagnose OSA (to be published as a sub-study)

Time frame: 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.