The main aim of the current study will be to compare the effects of ingesting different nitrate-rich sources on plasma nitrite concentrations.
Oral ingestion of nitrate (NO3-) has been shown to increase plasma nitrate and nitrite levels. Significant lowering of pulmonary oxygen uptake during exercise, as well as significantly lower blood pressure values at rest have been observed after supplementation with nitrate. However, no study has yet described a direct comparison between different nitrate-rich beverages with respect to the bioavailability of nitrate/nitrite and the possible hemodynamic effects. Based on the gaps in current literature, our main goal will therefore be to gain further insight into the effects of nitrate supplementation with different sources on plasma nitrite levels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
Maastricht University Medical Centre+
Maastricht, Limburg, Netherlands
Plasma nitrite levels
Plasma nitrite levels following ingestion of dietary nitrate
Time frame: Baseline until 5 hours after ingestion
Plasma levels of nitrate
Plasma nitrate levels following ingestion of dietary nitrate
Time frame: Baseline until 5 hours post-ingestion
Resting blood pressure
Resting blood pressure measures following ingestion of dietary nitrate
Time frame: Baseline, 2.5 hours and 5 hours post-ingestion
Tongue scraping to assess bacterial mouth flora.
Tongue scraping to assess bacterial mouth flora.
Time frame: 5 h post-ingestion
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