Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty Acids

Maastricht University Medical Center12 enrolled

Overview

In this placebo-controlled randomized parallel study the effects of a butyrate enema on plasma short-chain fatty acids (SCFA) concentrations and fluxes from portal drained viscera, liver and the splanchnic area are investigated

Patients undergoing upper abdominal surgery are included. During surgery they receive a butyrate enema or placebo enema. Before and after rectal administration, plasma samples are taken from several veins and arteries to analyse SCFA concentrations and fluxes from portal drained viscera, liver and the splanchnic area.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

SCFA Metabolism

Interventions

Sodium butyrateDIETARY_SUPPLEMENT

Patients recieved an enema containing butyrate or a placebo during upper abdominal surgery.

NaClDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing open liver resection or pancreaticoduodenectomy Exclusion Criteria: * known parenchymal liver disease * presence of ileostomy or colostomy * patients with inflammatory bowel disease * antibiotics, prebiotics or probiotics 2 months prior to surgery

Locations (1)

Maastricht University

Maastricht, Netherlands

Outcomes

Primary Outcomes

Plasma SCFAs

Time frame: 0, 5, 15, 30 min after administration

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.