Effect of Vitamin D Supplementation on Metabolic Parameters of Patients With Psoriasis

N/ACompletedNCT02271971

Pontificia Universidad Catolica de Chile39 enrolled

Overview

The purpose of this study is to determine whether supplementation with oral vitamin D (cholecalciferol) improves metabolic parameters in patients with moderate to severe psoriasis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Psoriasis Metabolic Syndrome Vitamin D Deficiency

Interventions

Vitamin D3DIETARY_SUPPLEMENT

A daily 5.000 IU vitamin D3 capsule during 6 weeks.

PlaceboDIETARY_SUPPLEMENT

A daily placebo capsule during 6 weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of moderate to severe psoriasis. * Being treated with methotrexate with stable doses for al least 1 month. Exclusion Criteria: * Phototherapy within the past 2 months. * History of psoriatic arthritis, rheumatoid arthritis, type 1 diabetes mellitus or inflammatory bowel disease. * Use of vitamin d supplements or fish oil supplements in the past 2 months. * Use of hypolipidemic drugs, hypoglycemic drugs, glucose sensitizers, oral corticosteroids, orlistat, cholestyramine, phenobarbital or phenytoin within the past 2 months. * Pregnancy or lactation.

Locations (1)

Pontificia Universidad Católica de Chile

Santiago, Santiago Metropolitan, Chile