Effects of Propofol on Early Recovery of Hunger After Surgery

University Hospital, Rouen116 enrolled

Overview

Recovery of hunger is a source of comfort for patients after general anesthesia. Moreover, this aspect of post-operative period is often required for discharging patients from hospital after ambulatory surgery. Indeed, this item is part of a multi-parameter score (Chung score) whose validation evaluates patient's ability to return home. The impact of anesthetics on hunger is largely unknown but few studies suggest an orexigenic effect of propofol compared to halogenated gases. These studies had neither the power nor the methodology to answer the question. The aim of our study is to evaluate the impact of propofol versus sevoflurane on early recovery of hunger after ambulatory surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

116

Conditions

Ambulatory Surgery Anesthesia Energy Expenditure Food Intake

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-45 years old women * American Society of Anesthesiologists (ASA) score 1-2 * Affiliated to a social security system * Undergoing an ambulatory surgery during more than 15 minutes with general anesthesia and control of upper airways (tracheal intubation or supraglottic mask or facial mask ventilation) for oocytes punction before in vitro fertilization * General anesthesia occuring between 8 and 10 am with respect of pre-operative fasting rules * APFEL risk score for nausea and vomiting ≤ 2/4 * Ability to understand and read french * Signature of understood consent Exclusion Criteria: * Other surgery than oocytes punction * Cognitive dysfunction * Undernutrition or risk factor of undernutrition (evolutive neoplasia, chronic alcoholism …) * BMI ≥ 35 kg/m² * Eating disorders * Diabetes mellitus * Chronic treatment with drugs modifying feeding behavior : * Benzodiazepines * Inhibitors of serotonin reuptake * Others * Non respect of pre-operative fasting rules * Indication for rapid sequence induction (gastro-oesophageal reflux, absence of gastric emptying …) * Contraindication to propofol (allergia to propofol, soybean or peanuts, past history of propofol infusion syndrome, unstable cardiovascular disease) or to sevoflurane (past history of malignant hyperthermia, epilepsy or liver disorders after administration of a halogenated anesthetic) * Pregnant or breastfeeding woman * Involvement in another clinical trial under 4 previous weeks

Outcomes

Primary Outcomes

Time before recovery of hunger after general anesthesia

Time before appearance of of hunger (evaluated by a score above 50/100 mm on analogic visual scale) after the end of hypnotic administration (propofol or sevoflurane).

Time frame: 1-4 hours

Secondary Outcomes

Feeding comfort

Amount of food intake evaluated by a specific scale

Time frame: 1-4 hours

Post operative nausea and vomiting

Time frame: 1-4 hours

Validation of Chung score

Time needed to obtain a Chung score superior or equal to 9/10, permitting the patient to return home

Time frame: 1-4 hours

Change in plasmatic leptin level

Change in plasmatic leptin level (expressed in ng/ml) at the end of anesthesia, one and two hours later, compared with pre-operative value for each patient. Dosage is realized by ELISA method.

Time frame: 0-3 hours

Change in plasmatic insulin level

Change in plasmatic insulin level (expressed in microU/ml) at the end of anesthesia, one and two hours later, compared with pre-operative value for each patient. Dosage is realized by ELISA method.

Time frame: 0-3 hours

Change in plasmatic ghrelin level

Change in plasmatic ghrelin level (expressed in pg/ml) at the end of anesthesia, one and two hours later, compared with pre-operative value for each patient. Dosage is realized by ELISA method.

Time frame: 0-3 hours

Effects of Propofol on Early Recovery of Hunger After Surgery

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes