Neurophysiological Assessment of Healthy and Impaired Human Lower Urinary Tract Function

Inclusion Criteria: healthy volunteers: * Written informed consent, * good mental and physical health, * age \>18y, Patients with LUTS and Patients with LUTS and treatment: * Written informed consent, * age \>18y, * prior urodynamic investigation, * LUTS since \>6months with or without detrusor overactivity Exclusion Criteria: healthy volunteers: * any neurological or urological pathology, * current pregnancy or lactation, * urinary tract infection, * hematuria, * any previous pelvic or spine or craniocerebral surgery, * any anatomical anomaly of the LUT or genitalia, * any metabolic disease, * any LUT malignancy, * bladder capacity \<150mL, * SDV at 60mL; Patients with LUTS and Patients with LUTS and treatment: * current pregnancy or lactation, * urinary tract infection, * gross hematuria