Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty

Peking Union Medical College Hospital74 enrolled

Overview

Evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.

Non-steroid anti-inflammatory drugs are recommended for multimodal postoperative pain management. We evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Pain, Postoperative

Interventions

Parecoxib sodiumDRUG

The patients in the parecoxib group received a single 40mg dose of parecoxib sodium 30 minutes before incision, 9:00 pm on the operation day as well as 9:00 am and 9:00 pm for the next two days after the operation, along with PCIA morphine.

Normal saline injectionDRUG

The patients in the control group received 2 mL normal saline injection 30 minutes before Normal saline injection incision, 9:00 pm on the operation day as well as 9:00 am and 9:00 pm for the next two days after the operation, along with PCIA morphine.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Male or female patients who have underwent primary unilateral total knee arthroplasty (TKA) and total hip arthroplasty (THA). 2. Age between 18-65 years. 3. Chinese ethnicity. Exclusion Criteria: 1. patients who underwent a reversion or a previous TKA or THA, emergency TKA, or TKA as result of a trauma. 2. patient exhibited allergy to parecoxib sodium. 3. lactating or pregnant. 4. any other conditions not suitable for surgery as evaluated by the surgeon in charge.

Locations (1)

The Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

To evaluate the Morphine consumption in each group patients

Time frame: 4 hours to 6 days after the surgery

Secondary Outcomes

To evaluate Patient-Controlled Intravenous Analgesia (PCIA) duration

Time frame: 4 hours to 6 days after the surgery

To evaluate the Visual Analog Scale (VAS) in each group patients underwent total knee arthroplasty and total hip arthroplasty

Time frame: 4 hours to 6 days after the surgery

Function recovery of knee Range of Motion (ROM) for patients received surgery

Time frame: 3 and 6 days after the surgery

Data from ClinicalTrials.gov

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