Exercise Prior to Allogeneic Hematologic Stem Cell Transplantation

University Health Network, Toronto30 enrolled

Overview

The investigators hypothesize that inactivity during the search for a donor may exacerbate current deconditioned states; subsequently, influencing risk factors for post-transplant complications that hinder the recovery phase. This study is designed to investigate if exercise therapy administered prior to allogeneic hematologic stem cell transplantation (HSCT) can influence physical and psychological side-effects associated with HSCT. Approximately 6-weeks prior to HSCT, individuals will be randomized into either an exercise group or usual care group and followed until one year after HSCT.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Allogeneic Stem Cell Transplantation

Interventions

Eligibility

Sex: ALLMin age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Medical indication: allogeneic stem cell transplantation at Princess Margaret Hospital * must be ambulatory without need for human assistance at time of recruitment * medically cleared to exercise by the transplant physician * demonstrates willingness to attend supervised sessions * sufficient in English to ensure safety of understanding prescribed exercise guidelines, or has access to an adequate non-familial interpreter Exclusion Criteria: * another active malignancy * less than 4 weeks till the scheduled HSCT * refusal to be randomized * does not have the approval of their transplant physician * severe or unstable neurological, cardiorespiratory, musculoskeletal disease or mental illness