A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre50 enrolled

Overview

Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis.

Periodontitis is a polymicrobial inflammatory disease which includes various modifiable and nonmodifiable risk factors. The non modifiable risk factors include genetic polymorphisms like metabolism associated genetic polymorphisms ( Vitamin D and Calcitonin). Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue with consequent increase in bone fragility and susceptibility to fractures. Bone loss is a common feature shared between periodontal disease and osteoporosis. Out of all genetic factors Calcitonin gene polymorphism contributes to the development of both osteoporosis and chronic periodontitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Generalized Chronic Periodontitis Osteoporosis

Interventions

CTR GeneGENETIC

2ml blood sample collected from patients to extract DNA for Assessment of CTR Gene polymorphism

Eligibility

Sex: ALLMin age: 35 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and Female * Patients aged between 35.00 Year(s) to 60.00 Year(s) diagnosed with Osteoporosis and Chronic Periodontitis who are willing to participate in the study Exclusion Criteria: * Patients who are Systemically compromised and under medications such as steroids. * Patients who smoke.Pregnant and lactating mothers are excluded from the study

Locations (1)

Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre

Hyderabad, Andhra Pradesh, India

Outcomes

Primary Outcomes

Calcitonin gene polymorphism

Collection of blood samples and running the samples by PCR

Time frame: 5 Months

Data from ClinicalTrials.gov

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