Research indicate that people who regularly drink tea have a reduced risk of stroke or heart disease. In a number of studies in which people that normally do not drink showed that their blood vessels function improved when the drunk tea. The current study tests whether a specific black tea improves vessel function in non-tea drinking hypertensive subjects.
Epidemiological studies indicate that regular consumption of three cups of black tea per day reduces the risk of stroke or myocardial infarction. In a number of previous nutrition intervention studies tea has been shown to improve vascular function as assessed by Flow Mediated Dilation in various populations. The current confirmatory study tests a specific black tea against a placebo in a population of in non-tea drinking hypertensive subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
30
Dept Clinical Pharmacology/CRF, St Thomas Hospital
London, United Kingdom
Flow Mediated Dilation
Flow mediated dilation (FMD) of the brachial artery was measured using vascular ultra sound and automated edge detection software: * 1 minute baseline scan to measure the baseline diameter of artery * 5 minutes of forearm occlusion at 250±30 mmHg, below the elbow (2-5 cm from antecubital crease) * 4 minutes FMD scan, which started immediately after release of occlusion Percentage FMD was calculated as the maximum increase in diameter after cuff release relative to the baseline diameter
Time frame: Before and 2 hours after test product intake
Endothelium-independent Vasodilation
Endothelium-independent dilation after glyceryl trinitrate defined as maximal percent increase in diameter
Time frame: 2.5 hours after test product intake
Systolic Blood Pressure Supine
Systolic blood pressure measured while lying down
Time frame: Before and 110 minutes after test product intake
Diastolic Blood Pressure Supine
Diastolic blood pressure measured while lying down
Time frame: Before and 110 minutes after test product intake
Systolic Blood Pressure Sitting
Systolic blood pressure measured while sitting
Time frame: Before and 90 minutes after test product intake
Diastolic Blood Pressure Sitting
Diastolic blood pressure measured while sitting
Time frame: Before and 90 minutes after test product intake
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