Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine

Ain Shams Maternity Hospital160 enrolled

Overview

Study to compare between efficacy of post-caesarean section infiltration with lidocaine and epinephrine versus lidocaine only to reduce post-incisional pain.

assessment of adding of epinephrine to lidocaine as local infiltrator to post-caesarean section wound in prolongation of its anaesthetic effect.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

DOUBLE

Enrollment

160

Conditions

Pain, Postoperative

Interventions

LidocaineDRUG

•The wound of C.Swill be infiltrated before closure of the skin, with 20 ml of 2% lidocaine.

lidocaine and EpinephrineDRUG

The wound of C.S will be infiltrated before closure of the skin, with 20 ml of 2% lidocaine and epinephrine in related dose manner 1:200.000.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women undergoing caesarean delivery under General anesthesia for various indications. * Women refuse spinal anesthesia. Exclusion Criteria: * Known or suspected sensitivity to local anesthesia. * Medical disorders induced by pregnancy (Pre-eclamptic toxemia, gestational diabetes mellitus, Hepatic diseases, homeostatic disorder) * Medical disorders aggravated by pregnancy (cardiovascular disease, pulmonary disease, renal disease, neurological disease, metabolic or infectious diseases). * Women who hemo-dynamically unstable. * Lack of adequate verbal communication.

Locations (1)

Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine;

Cairo, Egypt

Outcomes

Primary Outcomes

Timing of first analgesic request.

Time frame: 24 hours

Secondary Outcomes

Duration of cesarean section

Time frame: 30 min to 90 min

Onset of breast breastfeeding

Time frame: 24 hours

Onset of mobilization

first time patient start moving after the section

Time frame: 24 hours

Duration of hospital stay

Time frame: 24 hours to 48 hours

Side effects of local infiltration of lidocaine and epinephrine

Time frame: 7 days

Postoperative pyrexia

\<38°c

Time frame: 24 hours

Data from ClinicalTrials.gov

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