Biological Markers for the Diagnosis of Central Nervous System Infective Diseases

Xijing Hospital150 enrolled

Overview

Bacterial meningitis is a potentially life-threatening disease that is associated with substantial neurological morbidity and mortality. Accurate diagnosis is essential to improve outcome and prevent antibiotic overuse. Here we try to explore new biological markers for the diagnosis of the central nervous system infection disease.

To investigate the diagnosis value of procalcitonin,interleukin-6, agiotensininⅡin the cerebrospinal fluid in the central nervous system infection disease.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Infection

Eligibility

Sex: ALLMin age: 13 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Aged 13 years or older; 2. At least two of the following clinical characteristics:headache, fever, neck stiffness, mental symptoms or consciousness impairment or seizures 3. Patients' family signed informed consent. Exclusion Criteria: 1. Contraindications to lumbar puncture 2. Patients with active malignancy

Locations (1)

Xijing Hospital

Xi'an, Shaanxi, China

RECRUITING

Outcomes

Primary Outcomes

Levels of procalcitonin, interleukin-6, agiotensininⅡ in the serum and cerebrospinal fluid

meet the clinical diagnostic criteria for the central nervous system infection disease, the blood and cerebrospinal fluid samples after onset.

Time frame: 36 months

Central Contacts

jiang wen, MD

CONTACT

029-84771319 jiangwen@fmmu.edu.cn

Data from ClinicalTrials.gov

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