In this investigator-initiated study, we will compare changes in brain cognitive biomarkers assessed by diffusion tensor imaging over 2.5 years among 12 patients with Idiopathic Parkinson's disease (IPD) receiving rasagiline, 20 IPD patients not receiving MAO-B inhibitors and 25 age-matched healthy controls. Will also compare the changes in Mini-Mental State Exam (MMSE) and Montreal Cognitive Assessment (MoCA) scores and plasma brain-derived neurotrophic factor (BDNF) with changes in brain cognitive biomarkers in all IPD patients and HC over 2.5 years.
Study Type
OBSERVATIONAL
Enrollment
45
University at Buffalo
Buffalo, New York, United States
Change in cognitive biomarkers assessed by DTI
Time frame: 2.5 years
Comparison of change in cognitive biomarkers with change in MMSE and MoCA scores
Time frame: 2.5 years
Comparison of Baseline plasma BDNF with magnitude of change in brain cognitive biomarkers and MMSE and MoCA scores
Time frame: 2.5 years
Comparison of changes in plasma BDNF with changes in brain cognitive biomarkers and MMSE and MoCA scores
Time frame: 2.5 years
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