ATP in Alzheimer Disease

Inclusion Criteria: * 1\. Men and women aged 55-85 years * 2\. Diagnosis of possible or probable Alzheimer disease according to NIA-AA 2011 criteria. * 3\. Global Deterioration Scale Stadium 5-6 / 15-5 Mini-mental State examination * 4\. The patient is living with a family as a primary caregiver or a caregiver trained to accompany adequate and all intervention and follow-up visits. Patient and caregiver knowledge of local languages sufficient. * 5\. The patient and caregiver willing to participate in the study. There is a high probability that patient and caregiver to complete the study. * 6\. The patient has no sensory deficits preventing evaluation. * 7\. The patient receives a stable Alzheimer Disease conventional medication. No change in treatment at least 90 days prior to selection. * 8\. The patient receives a conventional stable medication for possible comorbidities. No change in treatment at least 90 days prior to selection. * 9\. The subject or his legal representative give prior informed consent that includes genetic studies of Apolipoprotein E and rs11870474. Exclusion Criteria: * 1\. Concomitant severe neurological disease Alzheimer Disease. * 2\. Presence or history of psychiatric disorders with an emphasis on positive behavioral disorders associated with Alzheimer Disease (aggressiveness, agitation, delusions, hallucinations, anxiety). * 3\. Current Severe systemic disease that may prevent completion of the study. * 4\. History STROKE. * 5\. History of convulsions and use of anticonvulsants. * 6\. History of myocardial infarction, angina pectoris, cardiac arrhythmias and other serious cardiovascular disorders such as congestive heart failure, and valvular aneurysms. * 7\. Background Diabetes mellitus and / or pictures of hypoglycemia. * 8\. Uncontrolled hypertension (systolic\> 160 mmHg and / or Diastolic\> 95 mmHg). * 9\. Systemic hypotension (SBP \<86 mmHg) or bradycardia (\<50 beats per minute) * 10\. Bronchial Asthma History or lung diseases that cause bronchospasm or bronchoconstriction * 11\. Kidney failure (patients with medical restrictions or income parenteral intake of fluids). * 12\. Liver failure. * 13\. Respiratory failure (need supplemental oxygen supply) * 14\. Blood donation in the last 90 days or anemia (Hb \<10g/dL) * 15\. Use connection (\<30 days prior to screening) of antidepressants, sedatives and hypnotics. * 16\. Using Alzheimer Disease experimental drugs in the last 60 days prior to screening. * 17\. Women who are pregnant or fertile * 18\. Inadequate venous access to prevent parenteral administration of infusions.