Brentuximab Vedotin for Relapsed/Refractory CD30-positive Non-Hodgkin Lymphomas

Inclusion Criteria: 1. Patients must have histologically confirmed non-Hodgkin lymphomas with CD 30 expression. Criteria of positive CD30 expression are defined as in cases with membranous CD30 expression from more than 50% of neoplastic cells. 2. Relapsed or progressed disease after two or more than two salvage chemotherapy 3. Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study. 4. Measurable disease \> 1.5 cm evidenced by computed tomography (CT) scan of the neck/chest/abdomen/pelvis or CT/positron emission tomography (PET) scans 5. Life expectancy of greater than 3 months 6. ECOG performance status ≤ 2 7. Male or female patients 18 - 75 years 8. Female patient is either post-menopausal for at least 1 year before the screening visit or surgically sterile or if of childbearing potential, agree to practice 2 effective methods of contraception, at the same time, from the time of signing the informed consent through 6 months after the last dose of study drug, or agrees to completely abstain from heterosexual intercourse. 9. Male patients, even if surgically sterilized, (i.e., status post vasectomy) agree to practice effective barrier contraception during the entire study period and through 6 months after the last dose of study drug, or agrees to completely abstain from heterosexual intercourse. 10. Voluntary written informed consent must be given before performance of any study-related procedure not part of standard medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care. 11. Clinical laboratory values as specified below within 7 days before the first dose of study drug: 12. Serum creatinine must be \< 2.0 mg/dL and/or creatinine clearance or calculated creatinine clearance \> 40 mL/minute. 13. Hemoglobin must be ≥ 8g/dL. 14. Absolute neutrophil count (ANC) ≥ 1500/uL 15. Platelets (Plts) ≥ 75,000/; G-CSF can be given prior to start of brentuximab vedotin and during brentuximab vedotin treatment to achieve target ANC; platelet transfusion can also be given prior to the start of brentuximab vedotin and during brentuximab vedotin treatment to achieve a target platelet ≥ 75,000/uL 16. Total bilirubin within 1.5 x of the upper limit of normal (ULN) institutional limits, patients with elevation of unconjugated bilirubin alone, as in Gilbert's disease, are eligible 17. Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) \< 2.5 X institutional ULN. AST and ALT may be elevated up to 5 times the ULN if their elevation can be reasonably ascribed to the presence of hematologic/solid tumor in liver Exclusion Criteria: 1. Hodgkin lymphoma 2. Anaplastic large cell lymphoma 3. Female patient who are both lactating and breast-feeding or have a positive serum pregnancy test during the screening period or a positive pregnancy test on Day 1 before first dose of study drug 4. Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to the protocol. 5. Known cerebral or meningeal disease (HL or any other etiology), including signs or symptoms of PML 6. Symptomatic neurologic disease compromising normal activities of daily living or requiring medications 7. Any sensory or motor peripheral neuropathy greater than or equal to Grade 2 8. Any active systemic viral, bacterial, or fungal infection requiring systemic antibiotics within 2 weeks prior to first study drug dose 9. Any prior treatment with chemotherapy and/or investigational agents completed less than 5 half-lives 10. Known hypersensitivity to recombinant proteins, murine proteins, or to any excipient contained in the drug formulation of brentuximab vedotin. 11. Known HIV antibody-positive 12. Known hepatitis B surface antigen-positive, or known or suspected active hepatitis C infection 13. Diagnosed or treated for another malignancy within 3 years before the first dose or previously diagnosed with another malignancy and have evidence of residual disease. Patients with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection. 14. Known history of any of the following cardiovascular conditions: * Myocardial infarction within 2 years of first dose of study drug * New York Heart Association (NYHA) Class III or IV heart failure (see Appendix 3) * Evidence of current uncontrolled cardiovascular conditions, including cardiac arrhythmias, congestive heart failure (CHF), angina, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities * A left-ventricular ejection fraction \<50% documented within 6 months before first dose of study drug