Examining Endogenous Antioxidant Levels in Well Trained Cyclists

University of Birmingham14 enrolled

Overview

This study will investigate whether increased habitual intake of antioxidant supplements effects the concentration of endogenous antioxidants, the response of antioxidants to exercise, and differences in oxidative damage compared to a non-supplemented group.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Oxidative Stress

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male, * BMI 18.8 29.9 kg/m2 * cycle 3-7 times a week for durations longer than 60 minutes * cycled for a minimum of 3 years * accustomed to exhaustive cycling protocols * healthy (no known cardiovascular or metabolic disease) Exclusion Criteria: * answering "NO" to any question on the general health questionnaire would result in exclusion from the study * current participation in another clinical study * current or recent smoker (last 30 days) * prescription or non-prescription of anti-inflammatory use \>30 days prior to the experiment commencing or any other medications that in the opinion of the investigator may interfere with redox signalling

Locations (1)

School of Sport Exercise and Rehabilitation Sciences, University of Birmingham

Birmingham, West Midlands, United Kingdom

Outcomes

Primary Outcomes

Difference in Resting Levels of Endogenous Antioxidant Proteins in Skeletal Muscle - Superoxide Dismutase 2 (SOD-2)

To examine the effects of habitual vitamin and antioxidant supplementation on endogenous antioxidant production, participants will have a muscle biopsy taken at rest to examine any differences in endogenous antioxidant protein concentrations

Time frame: Protein concentrations will be measured at baseline only

Data from ClinicalTrials.gov

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