Leptin and Ghrelin in ICU

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Overview

Enteral alimentation is the preferred modality of support in critical patients who have acceptable digestive function and are unable to eat orally, but the advantages of continuous versus intermittent administration are surrounded by controversy. This prospective, randomised study was designed to compare two enteral feeding methods with respect to changes in levels of leptin and ghrelin in ICU.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Critically Ill

Interventions

enteral feeding by nasogastric tube.OTHER

method of administration enteral feeding by nasogastric tube.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * who were unable to ingest an oral diet * given decision on enteral feeding Exclusion Criteria: * Carcinomatosis * irreversible coma * death or discharge before 14 days of observation * contraindication to enteral feeding * intolerance to the prescribed nutrients or infusion regimen * burn * multiple trauma * morbid obesity * end stage liver or renal or lung disease * severe sepsis or septic shock * patients with percutaneous endoscopic gastrostomy * immunosuppressive drug use * severe hemodynamic instability * massive blood transfusion

Locations (1)

Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital

Altinordu, Ordu, Turkey (Türkiye)

Outcomes

Primary Outcomes

Change from baseline in serum leptin concentration at three weeks in ICU

Time frame: first, 7th, 14th and 21th day

Change from baseline in serum ghrelin concentration at three weeks in ICU

Time frame: first, 7th, 14th and 21th day in ICU

Data from ClinicalTrials.gov

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