Validation of Drug Assays in Various Biological Matrices

Helen Reynolds100 enrolled

Overview

This study aims to ensure that assays that measure drug concentrations are accurate and precise in different matrices when quantified using high performance liquid chromatography -tandem mass spectrometry (HPLC-MS/MS). The study involves collecting samples of various bodily fluids to quantify antimicrobials, antivirals, oral contraceptives and erectile dysfunction agents. Samples will also be obtained from individuals not receiving these medications for quality control purposes.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Infection

Interventions

antivirals, antimicrobials, oral contraceptive, erectile dysfunction agentsOTHER

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years of age Exclusion Criteria: * Unable to give informed consent

Locations (1)

Royal Liverpool & Broadgreen Univeristy Hospitals NHS Trust

Liverpool, United Kingdom

RECRUITING

Outcomes

Primary Outcomes

To measure drug concentrations using high performance liquid chromatography -tandem mass spectrometry (HPLC-MS/MS) (accuracy and precision of assays that measure drug concentrations)

Assay validation

Time frame: Follow up up to 5 years

Central Contacts

Helen Reynolds

CONTACT

her@liv.ac.uk

Data from ClinicalTrials.gov

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