The primary objective of the study is to develop MS patient-matched healthy population norms for the Multiple Sclerosis Cognition Assessment Battery (MS-COG) that are representative of the United States (US), France, and Italy.
Study Type
OBSERVATIONAL
Enrollment
467
Research Site
Thornton, Colorado, United States
Research site
Decatur, Georgia, United States
Research Site
Latham, New York, United States
Research Site
Akron, Ohio, United States
Selective Reminding Test (SRT) Score
The SRT measures verbal learning and memory. A participant is read a list of words and then asked to recall as many of the words as possible. Six learning trials are conducted, followed by a delay trial approximately 20 to 40 minutes later.
Time frame: Day 1
Brief Visuospatial Memory Test-Revised (BVMT-R) Score
The BVMT-R measures visual learning and memory. The stimulus page is presented for 10 seconds, and the participant is then asked to reproduce the designs as accurately as possible and in the same location on the page. Three learning trials are administered, followed by a delay trial approximately 20 to 40 minutes later. Immediately following the delay trial a recognition trial is administered to see whether the participant recognizes the figures that were on the display.
Time frame: Day 1
2- second and 3-second Paced Auditory Serial Addition Test (PASAT) Score
The PASAT assesses auditory information processing speed. A random series of numbers from 1 to 9, inclusive, are presented and the participant is instructed to consecutively add pairs of numbers so that each number is added to the one that immediately preceded it. In the 2- and 3- second PASAT, numbers are presented at a rate of 1 every 2 or 3 seconds, respectively.
Time frame: Day 1
Symbol Digit Modalities Test (SDMT) Score
SDMT is a screening test for cognitive impairment. Participants are given 90 seconds in which to pair specific numbers with given geometric figures using a key. Scores range from 0 to 110 (best).
Time frame: Day 1
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Research site
Marseille, Bouches-du-Rhône, France
Research site
Bordeaux, Gironde, France
Research site
Milan, Milano, Italy
Research site
Roma, Roma, Italy